EMA Periodic Safety Update Report (PSUR) Guidance

EMA hub for EU PSUR submission requirements, EURD linkage, PSUSA assessment and post-authorisation procedural questions and answers.

Resource family Aggregate Reporting Resources
Resource type Psur Procedural Guidance
Maintained by European Medicines Agency
Jurisdiction European Union
Status Official EMA procedural guidance; read with GVP Module VII and applicable legislation
Access Public
Official link verified 2026-09-04
Official source Visit official resource ↗

EMA's PSUR hub brings together the operational framework for periodic safety update reporting in the EU.

Official resource

What the hub covers

The page explains submission requirements, the relationship with the EU reference dates (EURD) list, the PSUR single-assessment (PSUSA) procedure, assessment guidance and post-authorisation procedural questions and answers.

Practical use

Use this resource when determining whether and when a PSUR is due, how the report should be submitted, how PSUSA applies, and how an assessment outcome should be implemented.

The format and substantive content of the report are governed by applicable EU legislation and GVP Module VII. EMA procedural advice explains how those requirements are handled in practice and should therefore be read alongside the EURD list and the PSUR Repository resources.