Other
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5- Tisotumab Vedotin: Classification, Mechanism, Safety and Pharmacovigilance Tisotumab vedotin is a tissue-factor-directed antibody-drug conjugate carrying monomethyl auristatin E. Its pharmacovigilance profile is distinguished by ocular toxicity and required eye-risk controls, alongside haemorrhage, peripheral neuropathy, pulmonary toxicity and treatment-administration issues. Read Article →
- Brentuximab Vedotin: Classification, Mechanism, Safety and Pharmacovigilance Brentuximab vedotin is a CD30-directed antibody-drug conjugate carrying monomethyl auristatin E. Its pharmacovigilance profile is shaped by cumulative peripheral neuropathy, myelosuppression and infection, rare neurological and organ toxicities, and the changing attribution problem created by combination therapy. Read Article →
- Enfortumab Vedotin: Classification, Mechanism, Safety and Pharmacovigilance Enfortumab vedotin is a Nectin-4-directed antibody-drug conjugate carrying the microtubule-disrupting payload monomethyl auristatin E. Its pharmacovigilance profile is shaped by both target biology and payload toxicity, with particular attention to severe cutaneous reactions, hyperglycaemia, peripheral neuropathy, ocular events, pneumonitis and combination-regimen attribution. Read Article →
- Moroctocog Alfa: Classification, Mechanism, Safety and Pharmacovigilance Moroctocog alfa is a B-domain-deleted recombinant factor VIII replacement therapy for haemophilia A. Its pharmacovigilance profile centres on inhibitor development and unexpected lack of efficacy, laboratory recovery and assay interpretation, hypersensitivity, thrombosis, surgery, home administration and biological-product traceability. Read Article →
- Nonacog Alfa: Classification, Mechanism, Safety and Pharmacovigilance Nonacog alfa is a recombinant coagulation factor IX replacement therapy for haemophilia B. Its pharmacovigilance profile centres on treatment response and recovery, inhibitor formation, hypersensitivity including reactions associated with inhibitors, thrombosis, surgical use, home administration and biological-product traceability. Read Article →